Sappanchalcone, a flavonoid isolated fromCaesalpinia sappanL., induces caspase-dependent and AIF-dependentapoptosisin human coloncancercells^[1].

Sappanchalcone has a statistically significant effect on HCT116 cells than on SW480 cells (IC₅₀= 37.33 μM and 54.23 μM, respectively). Sappanchalcone reduces MMP with a significant increase in ROS levels in human colon cancer cells. Sappanchalcone triggered phosphorylation of p53, which is involved in the activation of caspases and increased expression of Bax in HCT116 cells^[1].

286.28

Solid

C₁₆H₁₄O₅

94344-54-4

• Flavonoids
• Chalcones

• Phenols
• Polyphenols

• Plants
• Leguminosae
• Caesalpinia sappanL.

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