E7766 disodium is a macrocycle-bridgedSTINGagonist with aK_dof 40 nM. E7766 disodium shows potent pan-genotypic and antitumor activities^[1].

E7766 disodium inhibits four human STING variants, human wild-type, HAQ, AQ and REF STING proteins, with EC₅₀values of 1 μM, 2.2 μM, 1.2 μM and 4.9 μM, respectively^[1].

In murine colon cancer model, a single intratumoral injection of 10 mg/kg E7766 disodium in the subcutaneous tumor. E7766 disodium is shown to have potent antitumor activity with long lasting immune memory response in a mouse liver metastatic tumor model^[1].

792.58

C₂₄H₂₆F₂N₁₀Na₂O₈P₂S₂

2242636-28-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.