ODN 21158 是一种有效的 G 修饰的TLR3和TLR9抑制剂。ODN 21158 没有细胞毒性。ODN 21158 以剂量依赖性方式抑制 IFN-α 分泌。
| 生物活性 | ODN 21158 is a potent G-modifiedTLR3andTLR9inhibitor. ODN 21158 shows no cytotoxic. ODN 21158 inhibits IFN-α secretion in a dose dependent manner[1]. |
体外研究
(In Vitro) | ODN 21158 (0.01, 0.1, 1, 10 μM) shows no cytotoxic in human PBMCs[1].
ODN 21158 (0.01, 0.1, 1, 10 μM; 24 h) inhibits IFN-α secretion in a dose dependent manner when stimulated with CpG-ODN 2216 (3 μM) in Human PBMCs[1].
ODN 21158 (0.01, 0.1, 1, 10 μM; 48 h) stimulated with CpG-ODN 2006 (100 nM) failes to inhibit IL-6 release of PBMCs[1].
ODN 21158 (0.01, 0.1, 1, 10 μM; 48 h) inhibits the release of IL-6 when stimulated with imiquimod (5 μg/ml) in human PBMCs[1].
ODN 21158 (0.1, 1, 10 μM; 24 h) inhibits the release of IL-6 in B-cells when stimulated with imiquimod (5 μg/ml) and CpG-ODN 2006 (100 nM)[1].
Cell Cytotoxicity Assay[1] | Cell Line: | human PBMCs | | Concentration: | 0.01, 0.1, 1, 10 μM | | Incubation Time: | 48 h | | Result: | Did not result in increased levels of extracellular LDH and not reduced the intracellular ATP-levels of CpG-ODN 2006-stimulated PBMCs. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
