Pyrantel

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Pyrantel

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

15686-83-6

Pyrantel 是一种口服有效的驱虫剂，也是烟碱乙酰胆碱受体 (nAChR) 激动剂。Pyrantel 可引起寄生虫的痉挛性肌肉麻痹。Pyrantel 可用于寄生虫感染的研究，比如蛔虫病、钩虫感染、肠虫病 (蛲虫感染)、毛霉菌病和旋毛虫病。

生物活性

Pyrantel is an orally active anthelmintic and an agonist of thenicotinic acetylcholine receptor(nAChR). Pyrantel can cause spasmodic muscle paralysis in parasites. Pyrantel can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis^[1]^[2].

IC₅₀& Target

Parasites^[1]^[2].

体外研究
(In Vitro)

Pyrantel (10 nM-10 μM; 72 h) shows good anti-A. suumand (0-168.2 M; 72 h) anti-N. americanusactivity^[1]^[2].

Cell Viability Assay^[1]

Cell Line:	A. suum
Concentration:	10 nM-10 μM
Incubation Time:	72 h
Result:	InhibitedA. suumwith a pEC₅₀value of 7.24.

Cell Viability Assay^[2]

Cell Line:	N. americanus
Concentration:	0-168.2 M (0-100 μg/mL)
Incubation Time:	72 h
Result:	Inhibited third-stage larvae and adult ofN. americanuswith IC₅₀values of 2.0 and 7.6 mg/mL, respectively.

体内研究
(In Vivo)

Pyrantel (10 mg/kg; p.o.; single) reduces the worms inA. ceylanicum-infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%^[2].

Animal Model:	Male Syrian Golden hamsters (3-week-old;A. ceylanicum-infected)^[2].
Dosage:	10 mg/kg
Administration:	Oral administration; single.
Result:	Exhibited worm burden reduction and worm expulsion rates of 87.2% and 63.4%, respectively.

Clinical Trial

分子量

206.31

Formula

C₁₁H₁₄N₂S

CAS 号

15686-83-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.