COG 133

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COG 133

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

514200-66-9

COG 133 是载脂蛋白 E (Apolipoprotein E, APOE) 肽的片段。COG 133 与 ApoE 全息蛋白竞争结合 LDL 受体，具有有效的抗炎和神经保护作用。COG 133 也是nAChR拮抗剂，IC₅₀为 445 nM。

生物活性

COG 133 is a fragment of Apolipoprotein E (APOE) peptide. COG 133 competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 is also anAChRantagonist with anIC₅₀of 445 nM^[1]^[2].

IC₅₀& Target

IC50: 445 nM (nAChR)^[2]

体内研究
(In Vivo)

COG 133 (1 mg/kg; intratracheal administration; every other day; for 4 weeks) treatment impairs the resolution of pulmonary fibrosis in mice^[3].

Animal Model:	Male C57BL/6 mice (6-week-old) instilled with Bleomycin^[3]
Dosage:	1 mg/kg
Administration:	Intratracheal administration; every other day; for 4 weeks
Result:	Did blunt the resolution of lung fibrosis.

分子量

2169.71

Formula

C₉₇H₁₈₁N₃₇O₁₉

CAS 号

514200-66-9

Sequence

Ac-Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu-Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu-NH2

Sequence Shortening

Ac-LRVRLASHLRKLRKRLL-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.