L-(+)-Abrine

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L-(+)-Abrine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

526-31-8

L-(+)-红豆碱
L-Abrine
L-N-Methyltryptophan
N-α-Methyl-L-tryptophan

L-(+)-Abrine 是在Abrus precatorius种子中发现的一种致命白蛋白，是一种急性毒性生物碱，可用作化学标记物。

生物活性

L-(+)-Abrine, a lethal albumin found inAbrus precatoriusseeds, is an acute toxic alkaloid and chemical marker for abrin.

体外研究
(In Vitro)

L-(+)-Abrine is a marker for abrin poisoning. A strong indication for abrin poisoning is the presence of the chemical maker L-(+)-Abrine, which can survive metabolism in significant amounts making it detectable in human urine^[1].

体内研究
(In Vivo)

Abrin is a toxic protein found in the jequirity seed. L-(+)-Abrine (L-Abrine) is also found in the jequirity seed and can be used as a biomarker for abrin exposure. An animal study is designed to monitor the excretion and recovery of L-(+)-Abrine in 20 rats. The animals are exposed to one of three concentrations of L-(+)-Abrine, a single high concentration of L-tryptophan, or no agent (control). The low L-(+)-Abrine dose corresponds to 0.63 LD₅₀i.p. abrin in mice, assuming a concentration ratio of 1:4 of abrin to L-(+)-Abrine and an LD₅₀for abrin of 20 μg/kg. The mid and high L-(+)-Abrine (250 and 400 μg/kg) doses are included to ensure that the target analyte can be detected and tracked over the course of the experiment^[2].

分子量

218.25

性状

Solid

Formula

C₁₂H₁₄N₂O₂

CAS 号

526-31-8

中文名称

L-(+)-相思子碱；L-(+)-相思豆碱；L-(+)-红豆碱

结构分类

Alkaloids
Indole Alkaloids

来源

Plants
Leguminosae
Abrus precatoriusLinn.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

H₂O : 1.85 mg/mL(8.48 mM;ultrasonic and adjust pH to 10 with NaOH)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	4.5819 mL	22.9095 mL	45.8190 mL
5 mM	0.9164 mL	4.5819 mL	9.1638 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。