Tumulosic Acid

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Tumulosic Acid

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CAS NO:

508-24-7

土莫酸

Tumulosic acid 是一种三萜类物质，可抑制KLK5蛋白酶活性 (IC₅₀=14.84 μM)。Tumulosic acid 在体外抑制角质形成细胞中 LL-37 的蛋白水解过程 (≤10 μM)。

生物活性

Tumulosic acid, a triterpenoid, inhibitsKLK5 proteaseactivity (IC₅₀= 14.84 μM). Tumulosic acid suppresses the proteolytic processing of LL-37 in keratinocytes at ≤10 μM^[1].

体外研究
(In Vitro)

Tumulosic acid displays dose-dependent anti-KLK5 activity (IC₅₀=19.3 μM)^[1].
Tumulosic acid decreases in LL-37 production in human keratinocytes^[1].
Tumulosic acid shows IC₅₀values of 14.84 and 10.48 μM against KLK5 and trypsin proteases, while it exhibited a weak inhibitory effect on KLK7 and chymotrypsin C proteases (19.5% and 4.0%, respectively, at 100 μM)^[1].

Western Blot Analysis^[1]

Cell Line:	Normal human epidermal keratinocytes (NHEKs)
Concentration:	1 μM and 10 μM
Incubation Time:	23 h in the presence of 10 μM cycloheximide
Result:	Decreased LL-37 production in epidermal keratinocytes.

分子量

486.73

Formula

C₃₁H₅₀O₄

CAS 号

508-24-7

中文名称

土莫酸

结构分类

Terpenoids
Triterpenes

来源

Plants
Polyporaceae
Poria cocos

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.