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Terazosin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Terazosin图片
CAS NO:63590-64-7
包装与价格：
包装价格(元)
50mg询价
250mg询价

Terazosin 是一种喹唑啉衍生物，是一种竞争性和口服活性的 α1-肾上腺素受体拮抗剂。
Cas No.63590-64-7
别名特拉唑嗪
化学名[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone
Canonical SMILESCOC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
分子式C19H25N5O4
分子量387.43
溶解度≥ 38.7mg/mL in DMSO with gentle warming
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Terazosin is an antagonist of α1-adrenergic receptor [1].

Terazosin is a long acting and selective α1-adrenergic-antagonist drug. The major use of it is the treatment for benign prostatic hyperplasia since it can relax the prostatic smooth muscle. Terazosin is proved to be a safe and effective treatment and has few adverse effects [1].

Besiedes, terazosin is also used to treat for hypertension. It is found to significantly decrease blood pressure in patients with uncomplicated hypertension. It is also found to effect blood lipids beneficially. Terazosin modestly lowers blood total cholesterol, low density lipoprotein cholesterol and triglycerides as well as increases high density lipoprotein. The beneficial effects make terazosin more potent to prevent coronary heart disease [2].

References:
[1] Lepor H, Williford W O, Barry M J, et al. The efficacy of terazosin, finasteride, or both in benign prostatic hyperplasia. New England Journal of Medicine, 1996, 335(8): 533-540.
[2] Grimm R H. alpha 1-antagonists in the treatment of hypertension. Hypertension, 1989, 13(5 Suppl): I131.

 
 
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