Deoxylimonin

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Deoxylimonin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

989-23-1

Desoxylimonin 是一种具有口服活性的三萜类化合物，可从葡萄柚种子中发现。Desoxylimonin 对乳腺癌细胞有抗增殖活性，其衍生物显示出更好的抗癌、镇痛和抗炎活性。

生物活性

Desoxylimonin is an orally active triterpenoid compound found from grapefruit seed. Desoxylimonin shows anti-proliferative activities to breastcancercells. Desoxylimonin derivatives shows better anticancer, analgesic and anti-inflammatory activity than the lead compound^[1].

体外研究
(In Vitro)

Deoxylimonin (0-90 μg/mL, 48 h) treatment shows anti-proliferation activities to breast cancer cells^[2].

Cell Proliferation Assay^[2]

Cell Line:	MDA-MB-435 and MCF-7 cells
Concentration:	0-90 μg/mL
Incubation Time:	48 hours
Result:	Showed IC₅₀values of 0.78 μg/mL and 2.50 μg/mL for MDA-MB-435 and MCF-7 cells, respectively.

体内研究
(In Vivo)

Deoxylimonin (oral administration; 70 mg/kg; once) treatment shows antinociception effects in vivo^[1].

Animal Model:	Mice injected with acetic acid^[1]
Dosage:	70 mg/kg
Administration:	Oral administration; 70 mg/kg; once
Result:	Showed the antinociception efficacy (writhing inhibition rate: 24.61%).

分子量

454.51

性状

Solid

Formula

C₂₆H₃₀O₇

CAS 号

989-23-1

结构分类

Terpenoids
Triterpenes

来源

Plants
Rutaceae
Citrus paradisiMacf.

Acinetobacter species

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO : 100 mg/mL(220.02 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.2002 mL	11.0009 mL	22.0017 mL
5 mM	0.4400 mL	2.2002 mL	4.4003 mL
10 mM	0.2200 mL	1.1001 mL	2.2002 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。