Phenserine ((-)-Eseroline phenylcarbamate) 是毒扁豆碱的衍生物，是一种强效、非竞争性、长效和选择性 AChE 抑制剂。
| Cas No. | 101246-66-6 |
| 别名 | 苯丝氨酸,(-)-Eseroline phenylcarbamate; (-)-Phenserine |
| 化学名 | (3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl phenylcarbamate |
| Canonical SMILES | O=C(NC1=CC=CC=C1)OC2=CC3=C(C=C2)N(C)[C@H]4N(C)CC[C@]43C |
| 分子式 | C20H23N3O2 |
| 分子量 | 337.42 |
| 溶解度 | DMF: 25 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml,Ethanol: 25 mg/ml |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | (+)-Phenserine is a novel selective cholinesterase noncompetitive inhibitor with an IC50 of 45.3 μM. References:
[1]. al-Jafari AA, et al. Kinetics of human erythrocyte acetylcholinesterase inhibition by a novel derivative of physostigmine: phenserine. Biochem Biophys Res Commun. 1998 Jul 9; 248(1):180-5. |
