4'',5''-Dehydroisopsoralidin

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CAS NO:

65639-51-2

4'',5''-Dehydroisopsoralidin 是一种 β-葡萄糖醛酸酶 (β-glucuronidase) 抑制剂(IC₅₀: 6.3 μM)。4'',5''-Dehydroisopsoralidin 具有抗炎和抗氧化作用。4'',5''-Dehydroisopsoralidin 可用于炎症和癌症的研究。

生物活性	4'',5''-Dehydroisopsoralidin is aβ-glucuronidaseinhibitor (IC₅₀: 6.3 μM). 4'',5''-Dehydroisopsoralidin has anti-inflammatory and anti-oxidative effects. 4'',5''-Dehydroisopsoralidin can be used in the research of inflammation and cancners^[1]^[2].
IC₅₀& Target	β-glucuronidase^[1]
体外研究 (In Vitro)	4'',5''-Dehydroisopsoralidin (compound 5, 15 min) inhibits the release of β-glucuronidase in polymorphonuclear leukocytes (PMNs) of rats, with an IC₅₀value of 6.3 μM^[1]. 4'',5''-Dehydroisopsoralidin (compound 9, 24 h) shows weak cytotoxicity (IC₅₀: >50 μM) to H4IIE, HCT116, C6 cells^[2]. 4'',5''-Dehydroisopsoralidin (25 μM, 1h) causes significant radical scavenging in H4IIE rat hepatoma cells (TEAC assay)^[2]. 4'',5''-Dehydroisopsoralidin (compound 5, 15 μM, 60 h) increases lifespan inP. corylifolia(MEP assay)^[3].
分子量	334.32
Formula	C₂₀H₁₄O₅
CAS 号	65639-51-2
结构分类	Phenylpropanoids Coumarins
来源	Plants Solanaceae Solanum lyratumThunberg
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.