Spiraeoside

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Spiraeoside

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

20229-56-5

Quercetin 4′-O-glucoside

Spiraeoside 是具有口服活性的天然产物，具有抗氧化活性，抑制活性氧和丙二醛的生成。Spiraeoside 具有抗过敏、抗炎、抗肿瘤活性。

生物活性

Spiraeoside, an orally active natural compound, exerts antioxidant activity, inhibitsreactive oxygen species(ROS)and malondialdehyde production. Spiraeoside possesses antiallergic, anti-inflammatory and antitumor activities^[1].

体外研究
(In Vitro)

Spiraeoside elevates HG stimulation-caused the decrease in the expression levels of p-Akt, nuclear Nrf2, and HO-1 in AC16 cells (the effects of Spiraeoside are reversed by LY294002)^[1].
Spiraeoside protects AC16 cells against HG-induced oxidative stress, cell injury, and apoptosis^[1].
Spiraeoside activates the PI3K/Akt/Nrf2 pathway in AC16 cells on exposure to HG^[1].
Spiraeoside protects AC16 cells against HG-induced apoptosis through the PI3K/Akt/Nrf2 pathway^[1].

Cell Viability Assay^[1]

Cell Line:	AC16 cells.
Concentration:	1, 5, 10, or 20 μM.
Incubation Time:	0, 24, or 48 hours.
Result:	Inhibited AC16 cells viability (20 μM).

体内研究
(In Vivo)

Spiraeoside (50 mg/kg, p.o.) shows ulcer preventive ability^[2].

Animal Model:	Male Wistar rats (6-8 weeks old)^[2].
Dosage:	50 mg/kg.
Administration:	Oral gavage an hour before inducing the lesions.
Result:	Decreased severity of the formed lesions.

分子量

464.38

性状

Solid

Formula

C₂₁H₂₀O₁₂

CAS 号

20229-56-5

中文名称

螺旋藻苷

结构分类

Flavonoids
Flavonones

Phenols
Polyphenols

来源

Plants
Liliaceae
Allium cepaL.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)