Corynoxine hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

Corynoxine hydrochloride 是一种从Uncaria macrophylla中分离出的四环羟吲哚生物碱。Corynoxine hydrochloride 是一种天然的自噬增强剂，可通过Akt/mTOR途径促进 α-突触核蛋白的清除。

生物活性

Corynoxine hydrochloride, a tetracyclic oxindole alkaloid, is isolated from the hooks ofUncaria macrophylla. Corynoxine hydrochloride is a naturalautophagyenhancer that promotes the clearance of alpha-synuclein viaAkt/mTORpathway^[1].

体外研究
(In Vitro)

Corynoxine (6.25-25 μM; 6-12 h) increases the expression of LC3-II, an autophagy specific marker, in N2a and SH-SY5Y cells in a dose-dependent manner^[1].
Corynoxine (25 μM; 48 h) promotes the degradation of wild type (WT) and mutant (A53T) α-syn in inducible PC12 cells via autophagy induction^[1].

Western Blot Analysis^[1]

Cell Line:	N2a and SH-SY5Y cells
Concentration:	6.25, 12.5, 25 μM
Incubation Time:	6, 12 hours
Result:	Induced autophagy in neuronal cell lines.

体内研究
(In Vivo)

Corynoxine (100-100 mg/kg; oral gavage) exhibits prolongation of the thiopental-induced hypnosis in mice^[2].
Corynoxine (10-100 μM for 12 h) induces autophagy in drosophila^[1].

分子量

420.93

Formula

C₂₂H₂₉ClN₂O₄

结构分类

Alkaloids
Indole Alkaloids

来源

Plants
Rubiaceae
Uncaria rhynchophylla(Miq.) Miq. ex Havil.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.