BChE-IN-11

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BChE-IN-11

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

133740-30-4

BChE-IN-11 (compound 10) 是一种有效的、选择性的、非竞争性BChE(丁基胆碱酯酶)抑制剂，其IC₅₀为 2.1 μM。BChE-IN-11 可用于阿尔茨海默病 (AD) 的研究。

生物活性

BChE-IN-11 (compound 10) is a potent, selective and non-competitiveBChE(butyrylcholinesterase) inhibitor, with anIC₅₀of 2.1 μM. BChE-IN-11 can be used for Alzheimer's disease (AD) research^[1].

IC₅₀& Target

BChE

2.1 ± 0.3 μM (IC₅₀)

AChE

体外研究
(In Vitro)

BChE-IN-11 (compound 10) shows inhibition activity for BChE and AChE, with inhibition of 96.6 ± 1.2% and 19.1 ± 3.8% at 25 μg/mL, respectively^[1].BChE-IN-11 binds to the active pocket of BChE via multiple hydrogen bonds with His438, Pro285, Gly115 and π–π stacking with Tyr332 and Trp82^[1].

分子量

346.38

Formula

C₂₂H₁₈O₄

CAS 号

133740-30-4

结构分类

Phenols
Polyphenols

来源

Plants
Orchidaceae
Bletilla striata

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.