Sinococuline

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Sinococuline

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

109351-36-2

Sinococuline 是一种有效的抗登革热病毒 (dengue virus) 剂，对所有四种登革热病毒 (DENV) 血清型均有效。Sinococuline 也是一种有效的肿瘤细胞生长抑制剂。

生物活性

Sinococuline is a potent anti-dengueagent that is effective against all four serotypes of dengue virus (DENV). Sinococuline is also an effective tumor cell growth inhibitor^[1]^[2].

体外研究
(In Vitro)

Sinococuline (0.5-5.0 μg/mL; 6 days) 抑制 DENV-2 感染的 Vero 细胞释放非结构蛋白-1 (NS1)^[1]。
Sinococuline (0-40 μg/mL; 48 h) 抑制 Vero 细胞中的泛 DENV 感染，对 DENV-1，DENV-2，DENV-3 和 DENV-4 的 IC₅₀值分别为 0.2，0.08，0.17 和 0.1 μg/mL^[1]。

体内研究
(In Vivo)

Sinococuline (0.5-2.0 mg/kg/day; i.p. twice a day for 5 days) 可降低严重 DENV 感染的 AG129 小鼠的发病率并提高其存活率，且不影响动物体重^[1]。

Animal Model:	AG129 mouse (an interferon type I and II receptor-deficient mice) with severe DENV-infection^[1]
Dosage:	0.5, 1.0, 2.0 mg/kg/day
Administration:	I.p. twice a day for 5 days
Result:	Showed delayed mortality and survived significantly of mice, but none of the mice could survive till the end of experiment at the dose of 0.5 mg/kg/day. The mice completely survived through the entire course of experiment at the dose of 2.0 mg/kg/day.

分子量

333.38

Formula

C₁₈H₂₃NO₅

CAS 号

109351-36-2

结构分类

Alkaloids
Piperidine Alkaloids

来源

Plants
Menispermaceae
Stephania japonica(Thunb.) Miers

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.