Arformoterol Tartrate

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CAS NO:

200815-49-2

酒石酸福莫特罗
(R,R)-Formoterol tartrate

Arformoterol ((R,R)-Formoterol) tartrate 是 Formoterol 的 (R,R)-对映异构体，是一种长效 β2-肾上腺素能受体 (β2-AR) 激动剂，K_d为 2.9 nM。Arformoterol tartrate 可用于慢性阻塞性肺疾病 (COPD) 的研究。

生物活性

Arformoterol ((R,R)-Formoterol) tartrate, the (R,R)-enantiomer of Formoterol, is a long-actingβ2-adrenergic receptor (β2-AR)agonist, with aK_dof 2.9 nM. Arformoterol tartrate can be used for the research of chronic obstructive pulmonary disease (COPD)^[1]^[2].

IC₅₀& Target^[1]

Beta-2 adrenergic receptor

2.9 nM (Kd)

体外研究
(In Vitro)

Arformoterol tartrate induces cAMP accumulation in cultured human bronchial epithelial cells^[1].

体内研究
(In Vivo)

Arformoterol tartrate (10 ng in 0.1 ml saline/20 g body weight; intranasal instillation) mitigates Cl₂-induced increases of respiratory system resistance and elastance in mice^[3].
Arformoterol tartrate reverses histamine- and ovalbumin-induced bronchoconstriction in guinea pigs (ED₅₀s=1 and 40 nmol/kg, respectively)^[1].

Animal Model:	Wild-type and iNOS^–/–mice were exposed to Cl₂gas^[3]
Dosage:	10 ng in 0.1 ml saline/20 g body weight
Administration:	Intranasal instillation in the external nares at 10 minutes and every 24 hours after exposure
Result:	Significantly mitigated the Cl₂-induced increases of respiratory system resistance and elastance. Increased cAMP in the lungs of Cl₂-exposed mice. Not mitigated Cl₂-induced lung injury and inflammation.

分子量

494.49

Formula

C₂₃H₃₀N₂O₁₀

CAS 号

200815-49-2

中文名称

酒石酸福莫特罗

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.