5-Nitro-1,10-phenanthroline

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CAS NO:

4199-88-6

5-NP

5-Nitro-1,10-phenanthroline (5-NP) 是一种 o-Phenanthroline (HY-W004544) 衍生物，是葡萄糖氧化酶 (GOX) 中介，具有抗结核菌活性。5-Nitro-1,10-phenanthroline 可作为氧化酶的氧化还原介质，适用于开发无试剂生物传感器和生物燃料电池。

生物活性

5-Nitro-1,10-phenanthroline (5-NP), is ao-Phenanthroline(HY-W004544) derivative, as a mediator ofglucose oxidase(GOX) with antituberculous activity. 5-Nitro-1,10-phenanthroline can be applied as redox mediators for oxidases and is suitable for the development of reagent-less biosensors and biofuel cells^[1]^[1].

体外研究
(In Vitro)

5-Nitro-1,10-phenanthroline (25 μM; 24 h) kills naturally resistant intracellular bacteria by inducing autophagy in THP-1 macrophages^[2].
5-Nitro-1,10-phenanthroline (1x, 5x, 20x or 50x MIC, MIC=0.78 μM; 1 h) also modulates the host machinery to kill intracellular pathogens by inhibiting mycolic acid biosynthesis of Mtb^[2].

Cell Viability Assay^[2]

Cell Line:	Mtb H37Rv,M. bovisBCG andM. bovisBCG-5NP resistant strain
Concentration:	0-12.5 μM
Incubation Time:	24 hours
Result:	Inhibited pathogens with MIC₉₉values of 0.78 μM (Mtb H37Rv), 0.78 μM (M. bovisBCG), and >12.5 μM (M. bovisBCG-5NP), respectively.

分子量

225.20

性状

Solid

Formula

C₁₂H₇N₃O₂

CAS 号

4199-88-6

中文名称

5-硝基-1,10-邻菲啰啉

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)