Cefepime chloride

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Cefepime chloride

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

107648-79-3

BMY-28142 chloride

Cefepime (BMY-28142) chloride 是一种广谱且能穿过血脑屏障的头孢菌素。Cefepime chloride 对革兰氏阳性和革兰氏阴性需氧菌均有抗菌作用。Cefepime chloride 会引起神经毒性。

生物活性

Cefepime (BMY-28142) chloride is a broad-spectrum and cross the blood-brain barrier cephalosporin. Cefepime chloride shows antibacterial effects against both Gram-positive and Gram-negative aerobic bacteria. Cefepime chloride induces neurotoxicity^[1]^[2]^[3]^[4].

体外研究
(In Vitro)

Cefepime chloride exerts its antibacterial effects by binding to penicillin-binding proteins^[2].

体内研究
(In Vivo)

Cefepime chloride (80 mg/kg; i.p.) significantly increases the half-life and mice surviveed^[4].

Animal Model:	Male CD-1 mice^[4]
Dosage:	80 mg/kg
Administration:	I.p.
Result:	Significantly prolonged the half-life of cefepime and all mice survived at 18-22 mg/kg cisplatin, and when pretreatment with 26 mg/kg cisplatin significantly decreased survival with the half-life of cefepime was not significantly longer than of 18 mg/kg cisplatin.

Clinical Trial

分子量

517.02

Formula

C₁₉H₂₅ClN₆O₅S₂

CAS 号

107648-79-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.