Olprinone Hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

119615-63-3

盐酸奥普力农
Loprinone Hydrochloride

Olprinone (Loprinone) Hydrochloride 是一种有效的磷酸二酯酶(PDE) 3抑制剂，对 PDE1，PDE2，PDE3，PDE4 的IC₅₀分别为 150、100、0.35 和 14 μM。Olprinone Hydrochloride 因其正性肌力和血管扩张作用而被用于心力衰竭的研究。Olprinone Hydrochloride 具有抗炎活性。

生物活性

Olprinone (Loprinone) Hydrochloride is a potentphosphodiesterase (PDE)3inhibitor, withIC₅₀s of 150, 100, 0.35 and 14 μM forPDE1,PDE2,PDE3andPDE4, respectively. Olprinone Hydrochloride is used for the research of heart failure due to its positive inotropic and vasodilative effects. Anti-inflammatory activity^[1]^[2].

体内研究
(In Vivo)

Olprinone (Loprinone) Hydrochloride (0.2 mg/kg; i.p.) modulates the inflammation associated with myocardial ischemia-reperfusion injury in rats^[1].

Animal Model:	Male adult Wistar rats (250-300 g) (ischemia–reperfusion rats)^[1]
Dosage:	0.2 mg/kg
Administration:	I.p. (administered 15 min after ischemia)
Result:	Significantly reduced the: (1) histological evidence of myocardial injury, (2) pro-inflammatory cytokines: tumor necrosis factor-α (TNF-α) and Interleukin-1β (IL-1β), (3) adhesion molecules: Inter-Cellular Adhesion Molecule 1 (ICAM-1) and P-Selectin, (4) nitrotyrosine formation, (5) nuclear factor kappa-B (NF-κB) expression, (6) Poly (ADP-ribose) (PAR) formation, and (7) apoptosis (Bax, Bcl-2, Fas-L and terminal deoxynucleotidyl transferase-mediated UTP end labeling (TUNEL).

分子量

286.72

性状

Solid

Formula

C₁₄H₁₁ClN₄O

CAS 号

119615-63-3

中文名称

盐酸奥普力农

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H₂O : ≥ 7.69 mg/mL(26.82 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	3.4877 mL	17.4386 mL	34.8772 mL
5 mM	0.6975 mL	3.4877 mL	6.9754 mL
10 mM	0.3488 mL	1.7439 mL	3.4877 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。