PF-CBP1是CREB结合蛋白溴区的高度选择性抑制剂。
| 生物活性 | PF-CBP1 is a highly selective inhibitor of the CREB binding protein bromodomain[1]. |
体外研究
(In Vitro) | PF-CBP1 modulates key inflammatory genes in primary macrophages. PF-CBP1 downregulates RGS4 in neurons, a target linked to Parkinson's disease. PF-CBP1 is 139-fold selective over BRD4 in the biochemical assays and >105-fold selective by ITC. F-CBP1 is also a potent inhibitor of EP300 (a result observed for other CBP inhibitors[1].
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
