GSK9311 hydrochloride

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CAS NO:

2253733-09-2

GSK9311 hydrochloride 是一种活性较低的 GSK6853 类似物，可用作阴性对照。GSK9311 hydrochloride 抑制BRPF溴结构域，对 BRPF1 和 BRPF2 的pIC₅₀值分别为 6.0 和 4.3。

生物活性

GSK9311 hydrochloride, a less active analogue of GSK6853, can be used as a negative control. GSK9311 hydrochloride inhibitsBRPF bromodomainwithpIC₅₀values of 6.0 and 4.3 forBRPF1andBRPF2, respectively^[1].

IC₅₀& Target

BRPF1

6.0 (pIC₅₀)

BRPF2

4.3 (pIC₅₀)

体外研究
(In Vitro)

GSK6853 is a potent (300 pM), soluble, cell active (20 nM), and highly selective inhibitor of the BRPF1 bromodomain, and demonstrates properties suitable for cellular and in vivo studies. GSK6853 is a less active analogue of GSK6853 in which the 5-amide is alkylated^[1].

分子量

474.00

Formula

C₂₄H₃₂ClN₅O₃

CAS 号

2253733-09-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.