PD 168568 dihydrochloride

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CAS NO:

1782532-06-2

PD 168568 dihydrochloride 是一种口服有效的多巴胺受体 D₄(DRD₄) 拮抗剂。PD 168568 dihydrochloride 含有异吲哚啉酮，对 D₄受体相对于 D₂和 D₃具有选择性，其K_i值分别为 8.8、1842 和 2682 nM。PD 168568 dihydrochloride 可用于胶质母细胞瘤 (GBM) 研究。

生物活性

PD 168568 dihydrochloride is a orally active and potentdopamine receptorD₄(DRD₄)antagonist. PD 168568 dihydrochloride contains an isoindolinone and is selective for theD₄receptorversus D₂and D₃, withK_ivalues of 8.8, 1842, and 2682 nM, respectively. PD 168568 dihydrochloride can be used for glioblastoma (GBM) research^[1]^[2].

IC₅₀& Target^[1]

D₄Receptor

8.8 nM (Ki)

D₂Receptor

1842 nM (Ki)

D₃Receptor

2682 nM (Ki)

体外研究
(In Vitro)

PD 168568 dihydrochloride 对胶质母细胞瘤神经干细胞 (GNS) 表现出选择性抑制，IC₅₀为 25-50 μM^[1]。

体内研究
(In Vivo)

PD 168568 dihydrochloride (3 mg/kg，口服) 可抑制大鼠 amphetamine 刺激的运动活动^[3]。

Animal Model:	Rat^[1]
Dosage:	3 mg/kg
Administration:	Oral administration
Result:	Inhibit amphetamine (0.5 mg/kg, i.p.) stimulated locomotor activity.

分子量

422.39

Formula

C₂₂H₂₉Cl₂N₃O

CAS 号

1782532-06-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.