Decylubiquinone

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Decylubiquinone

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CAS NO:

55486-00-5

包装与价格：

包装	价格(元)
5mg (7.753 mM * 2 mL in Ethanol)	询价
10mg (15.506 mM * 2 mL in Ethanol)	询价

癸基泛醌

Decylubiquinone 是泛醌 (辅酶 Q₁₀) 的类似物。Decylubiquinone 阻止活性氧 (ROS) 的产生以响应谷胱甘肽消耗并抑制线粒体通透性转变的激活。

生物活性

Decylubiquinone is an analog of ubiquinone (coenzyme Q₁₀). Decylubiquinone blocksreactive oxygen species(ROS)production in response to glutathione depletion and inhibits activation of the mitochondrial permeability transition^[1].

体外研究
(In Vitro)

Decylubiquinone (dUb; 10 μm for 6 hours) exerts its effects on ROS by either inhibition of ROS production by cytochrome bc1 or that it scavenged ROS produced^[1].
Decylubiquinone inhibits both the dichlorofluorescein (DCF) fluorescence increase resulting from H₂O₂treatment and the DCF fluorescence increase resulting after glutathione (GSH) depletion using diethylmaleate mitochondrially generated ROS)^[1].

Cell Viability Assay^[1]

Cell Line:	HL60 cells transfected with bcl-2 (bcl-2) (HL60 B cells)
Concentration:	10 μM
Incubation Time:	6 hours
Result:	Attenuated the ROS increase in HL60 (B) cells.

分子量

322.44

性状

Liquid

Formula

C₁₉H₃₀O₄

CAS 号

55486-00-5

中文名称

癸基泛醌

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Solution, -20°C, 2 years