Betamethasone hydrochloride

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CAS NO:

956901-32-9

盐酸倍他米松

Betamethasone hydrochloride 是一种合成糖皮质激素，具有抗炎和免疫抑制活性。Betamethasone hydrochloride 可加速胎儿肺成熟并诱导基因表达和细胞凋亡。

生物活性

Betamethasone hydrochloride is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone hydrochloride accelerates fetal lung maturation and induces gene expression andapoptosis^[1]^[2]^[3]^[4].

体外研究
(In Vitro)

Betamethasone (0.1-1 μM; 12 h) induces gene expression in L929 cells^[4].
Betamethasone (0.1-1 μM; 48 h) induces CEM C7 T-cells apoptosis^[4].

体内研究
(In Vivo)

Betamethasone (0.48 mg; i.v.gtt for 48 h) decreases the hypercapnia-induced increase in CBF due to decreased cerebral vasodilatation^[1]. Betamethasone (0.05 ml (1 mg/L); topical injection) ameliorates spinal nerve transection induced mechanical allodynia and thermal hyperalgesia, and reduces the activation of NF-κB and elevation of TNFα and IL-1β, and induces the expression of IL-10 in the rats brain^[2].

Animal Model:	Rambouillet-Colombia ewes bred on a single occasion are received hypercapnic challenges^[1]
Dosage:	0.48 mg
Administration:	Injected into the fetal jugular vein at a rate of 1 ml/h (10 μg betamethasone/h) and maintained over the next 48 h.
Result:	Decreased cerebral blood flow (CBF) in all brain regions measured except the hippocampus after 24 h of infusion. The reduction in CBF was diminished to about 25-30 % after 48 h of infusion.

Clinical Trial

分子量

428.92

Formula

C₂₂H₃₀ClFO₅

CAS 号

956901-32-9

中文名称

盐酸倍他米松

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.