C188是一种STAT3抑制剂，通过靶向STAT3 SH2结构域的肽结合口袋，抑制IL -6诱导的STAT3磷酸化和HepG2细胞的核易位。C188在体外诱导乳腺癌细胞MB-MDA-468 的凋亡中表现出较高的活性(EC50= 0.7 μM)。
| 生物活性 | C188 is aSTAT3inhibitor that inhibits IL-6-stimulatedSTAT3phosphorylation and nuclear translocation in HepG2 cells by targetingSTAT3SH2 domain peptide-binding pocket. C188, in particular, was highly active in inducingapoptosisof the breastcancercell line MB-MDA-468 in vitro (EC50= 0.7 μM). |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | | Powder | -20°C | 3 years | | 4°C | 2 years | | In solvent | -80°C | 6 months | | -20°C | 1 month |
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