Semilicoisoflavone B

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CAS NO:

129280-33-7

半甘草异黄酮 B

Semilicoisoflavone B，一种异黄酮，主要来源于Glycyrrhiza uralensisFisch.。Semilicoisoflavone B 通过抑制 β-分泌酶-1 (BACE1) 的表达和活性来减少淀粉样蛋白 β (amyloid β，Aβ) 的分泌。Semilicoisoflavone B 主要通过增加 PPARγ 表达和抑制 STAT3 磷酸化来降低 BACE1 的表达。

生物活性	Semilicoisoflavone B, an isoflavone, mainly derived fromGlycyrrhiza uralensisFisch.. Semilicoisoflavone B reducesamyloid β(Aβ) secretion by inhibiting β-secretase-1 (BACE1) expression and activity. Semilicoisoflavone B decreasesBACE1expression mainly through increasingPPARγexpression and inhibitingSTAT3phosphorylation^[1].
分子量	352.34
性状	Solid
Formula	C₂₀H₁₆O₆
CAS 号	129280-33-7
中文名称	半甘草异黄酮 B
结构分类	Flavonoids Isoflavones Phenols Polyphenols
来源	Plants Leguminosae Glycyrrhiza uralensisFisch.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)