Niacin hydrochloride

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CAS NO:

636-79-3

Nicotinic acid hydrochloride
Vitamin B3 hydrochloride

Niacin (Vitamin B3; Nicotinic acid) hydrochloride 是一种具有口服活性的 B3 维生素 (B3 vitamin)，是人类必需的营养物质。Niacin hydrochloride 在能量代谢、细胞信号级联调节基因表达和细胞凋亡 (apoptosis) 中起关键作用，也可用于心血管疾病的研究。

生物活性

Niacin (Vitamin B3; Nicotinic acid) hydrochloride is an orally activeB3 vitaminthat is an essential nutrient for humans. Niacin hydrochloride plays a key role in energy metabolism, cell signaling cascades regulating gene expression andapoptosis. Niacin hydrochloride is also used in the study of cardiovascular diseases^[1]^[2].

IC₅₀& Target

Microbial Metabolite

Human Endogenous Metabolite

体外研究
(In Vitro)

Niacin hydrochloride (0-900 μM, 42 hours) significantly increases GSH levels and decreases ROS levels, and affects the expression of genes related to apoptosis and lipid metabolism^[1].
Niacin hydrochloride (0-40 μM, 24 hours) can inhibit cancer invasive activity at low dose but with no influence on proliferation^[2].

RT-PCR^[1]

Cell Line:	Cumulus cells and oocytes of prepubertal gilts
Concentration:	600 μM
Incubation Time:	42 hours
Result:	Up-regulated the relative expression of the anti-apoptotic gene BCL2 and lipid metabolism gene ACACA while down-regulated the pro-apoptotic gene BAX.

Cell Proliferation Assay^[2]

Cell Line:	Rat ascites hepatoma cell line of AH109A
Concentration:	0-40 μM
Incubation Time:	24 hours
Result:	Had no effect on the proliferation of AH109A cells but suppressed cell invasion from 2.5 μM to 40 μM.

体内研究
(In Vivo)

Niacin hydrochloride (subcutaneous injection, 3-300 mg/kg, once) can induce vasodilation in a dose-dependent manner within minutes in male C57BL/6 mice^[3].

Animal Model:	Male C57BL/6 mice^[3]
Dosage:	3-300 mg/kg
Administration:	Subcutaneous injection; once
Result:	Induced vasodilation in a dose-dependent manner.

Clinical Trial

分子量

159.57

Formula

C₆H₆ClNO₂

CAS 号

636-79-3

中文名称

烟酸盐酸盐；B3维生素；尼克酸盐酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.