L-Homocysteic acid (L-HCA) 是一种内源性兴奋性氨基酸，可作为NMDA受体激动剂 (EC50: 14 μM)。L-Homocysteic acid 具有神经毒性，可用于神经系统疾病的研究。
| 生物活性 | L-Homocysteic acid (L-HCA) is an endogenous excitatory amino acid that acts as aNMDAreceptor agonist (EC50: 14 μM). L-Homocysteic acid is neurotoxic, and can be used in the research of neurological disorders[1][2][3]. |
| IC50& Target[1] | NMDA Receptor 14 μM (EC50) |
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体外研究
(In Vitro) | L-Homocysteic acid activates NMDA receptor with an EC50value of 14 μM[1].
L-Homocysteic acid (100 μM) induces large currents (1.8 nA) that is insensitive to the NMDA receptor-antagonist mixture in Purkinje cells[1].
L-Homocysteic acid (250 μM, 30 min) potently induces an acute excitotoxic reaction inex vivochick embryo retina[2].
L-Homocysteic acid (0-2 mM, 48 h) induces a concentration-dependent neurotoxic effect in rat primary neurons[3].
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体内研究
(In Vivo) | L-Homocysteic acid (intraperitoneal injection, 4-11 mmol/kg) elicits seizures in rats during early postnatal development[4].
L-Homocysteic acid (intraperitoneal injection, 100-1500 mg/kg) partially substitutes for NMDA, producing maximum values of 61-67% NMDA-lever responding at doses of 1000 and 560 mg/kg, respectively in Sprague-Dawley rats[5].
| Animal Model: | Male albino rats of the Wistar strain[4] | | Dosage: | 4, 5.5, 8, 11 mM/kg | | Administration: | Intraperitoneal injection, daily for 14 days | | Result: | Induced flexion seizures at 4 mmol/kg.
Led to intense tail flicking, pivoting, and locomotion.
Decreased ECoG (electrocorticograms) activity for 5-9 min. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
