Dithiodipropionic acid

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CAS NO:

1119-62-6

3,3'-二硫代二丙酸

Dithiodipropionic acid 可与 CPUL1 (HY-151802,TrxR抑制剂) 相互作用形成纳米聚集体 (CPUL1-DA NAs)。CPUL1-DA NAs 可比游离 CPUL1 产生更丰富的活性氧 (ROS) 并诱导细胞凋亡 (apoptosis)，提高抗 HUH7 癌细胞的抗肿瘤功效。

生物活性

Dithiodipropionic acid can interact withCPUL1(HY-151802, aTrxRinhibitor) to form nanoaggregates (CPUL1-DA NAs). CPUL1-DA NAs generates more abundantROSto induce cellapoptosisthan that of free CPUL1, and improves antitumor efficacy against HUH7cancercells^[1].

体外研究
(In Vitro)

CPUL1-DA NAs (molar ratio was 1:2) inhibits HUH7 hepatoma cell viability with an IC₅₀value of 4.3 μM, and has weak cytotoxicity against normal L02 cells^[1].
CPUL1-DA NAs (2.5-10 μM, 6 h) can be more effectively enriched in HUH7 cells mitochondria and displays faster cellular uptake ability to deliver CPUL1 into cells than that of free CPUL1^[1].
CPUL1-DA NAs (2.5-10 μM, 12 h) results in the accumulation of superoxides and mitochondrial membrane damage in HUH7 cells^[1].

分子量

210.26

性状

Solid

Formula

C₆H₁₀O₄S₂

CAS 号

1119-62-6

中文名称

3,3'-二硫代二丙酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month