(2S,3R)-LP99

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(2S,3R)-LP99

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1808948-28-8

(2S,3R)-LP99 是一种有效的选择性BRD7和BRD9抑制剂，BRD9 的K_D值为 99 nM。(2S,3R)-LP99 在体外和细胞中抑制 BRD7 和 BRD9 与乙酰化组蛋白的结合。(2S,3R)-LP99证明 BRD7/9 在调节促炎细胞因子分泌中发挥作用。

生物活性

(2S,3R)-LP99 is a potent and selectiveBRD7andBRD9inhibitor with anK_Dof 99 nM forBRD9. (2S,3R)-LP99 inhibits the association ofBRD7andBRD9to acetylated histones in vitro and in cells. (2S,3R)-LP99 demonstrates that BRD7/9 plays a role in regulating pro-inflammatory cytokine secretion^[1].

IC₅₀& Target^[1]

BRD7	BRD9 99 nM (Kd)

体外研究
(In Vitro)

(2S,3R)-LP99 (compound 60) (0-100 μM) inhibits the expression of IL6 in LPS-stimulated (100 ng/mL) THP-1 cells^[1].

分子量

516.05

Formula

C₂₆H₃₀ClN₃O₄S

CAS 号

1808948-28-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.