Enclomiphene ((E)-Clomiphene) hydrochloride 是一种有效的、可口服的非甾体雌激素受体 (estrogen receptor) 拮抗剂，具有抗雌激素作用。Enclomiphene hydrochloride 可用于卵巢功能障碍、睾酮缺乏、男性性腺功能减退症和 type 2 型糖尿病的相关研究。
| 生物活性 | Enclomiphene ((E)-Clomiphene) hydrochloride is a potent and orally active non-steroidalestrogen receptorantagonist, with antioestrogenic property. Enclomiphene hydrochloride can be used for the research of ovarian dysfunction, testosterone deficiency, male hypogonadism and type 2 diabetes[1]. |
体外研究
(In Vitro) | Enclomiphene hydrochloride (0-100 μM, 6 h) dose-dependently inhibits basal and gonadotrophin-stimulated small and large ovine luteal cell progesterone secretion[2].
Enclomiphene hydrochloride (0-100 μg/mL, 24 h) dose-dependently inhibits fertilization rates, blastocyst formation rates, and degeneration rates in mouse oocytes[3].
Enclomiphene hydrochloride (1 nM-10 μM, 6 h) dose-dependently decreases E2-induced inhibition of follicle stimulating hormone (FSH) secretion in primary sheep pituitary cells[4].
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体内研究
(In Vivo) | Enclomiphene hydrochloride (subcutaneous injection, 0.25 and 0.5 mg/animal, daily) inhibits spermatogenesis and decreases serum luteinizing hormone (LH) and testosterone levels in intact or castrated rats[5].
Enclomiphene hydrochloride (oral adminstration, 0.03-3 mg/kg, daily for 90 days) reductes body weight to sham levels, and reduced serum cholesterol[6].
| Animal Model: | 21 days-old Charles River male rats[5] | | Dosage: | 0.25 and 0.5 mg/animal, daily for 24 days. | | Administration: | Subcutaneous injection | | Result: | Decreased LH and testosterone levels in the serum. |
| Animal Model: | OVX (ovariectomy) rat model[6] | | Dosage: | 0.03, 1, and 3 mg/kg, daily for 90 days. | | Administration: | Oral adminstration | | Result: | Reducted body weight to sham levels, and reduced serum cholesterol.
Showed dose-dependent effects on the proximal tibia with BMD and BMC approaching posttreatment Sham levels. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
