| CAS NO: | 1009734-33-1 |
| 包装 | 价格(元) |
| 5mg | 询价 |
| 25mg | 询价 |
| Cas No. | 1009734-33-1 |
| 别名 | 5-叔丁氧基-2,4-二氨基喹唑啉 |
| 化学名 | 5-(tert-butoxy)quinazoline-2,4-diamine |
| Canonical SMILES | NC1=NC(N)=NC2=CC=CC(OC(C)(C)C)=C21 |
| 分子式 | C12H16N4O |
| 分子量 | 232.28 |
| 溶解度 | ≥ 11.6mg/mL in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | HZ-1157 is a potent hepatitis C virus (HCV) inhibitor toward HCV NS3/4A protease with IC50 value of 1.0 μmol/L [1]. The NS3 protease of HCV is a prime target for the development of anti-HCV agents because it cleaves the viral polyprotein and liberates NS3, NS4A, NS4B, NS5A, and NS5B, allowing them to function normally in viral RNA replication, and it deactivates many host proteins involved in innate immunity to foster a favorable cellular environment for HCV replication. The NS3 protease is most active when complexed with its cofactor NS4A [1]. In vitro: Huh7.5.1 cell line stably transfected with HCV NS3/4A protease reporter was established to investigate the anti-HCV mechanism of HZ-1157 (0.001~1 μmol/L). The results showed that HZ-1157 exhibited inhibitory effect on the HCV NS3/4A protease with IC50 value of 1.0 μmol/L. HZ-1157 was further tested against an infectious HCV virus (J399EM) which can infect and replicate in Huh7.5.1 cells in vitro. The results showed that HZ-1157 effectively inhibited J399EM virus replication in Huh7.5.1 cells with IC50 value of 0.82 μmol/L [1]. Reference: |
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