Fmoc-L-Asn(EDA-N3)-OH

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CAS NO:

2616562-74-2

Fmoc-L-Asn(EDA-N3)-OH 是一种含有叠氮基团的点化学试剂。文献报道了该构建块通过点击化学修饰羊草素。羊草素是死亡帽蘑菇产生的酪毒素肽家族中最致命的一种，是一种口服的刚性双环八肽，是已知的最致命的天然产物之一 (LD₅₀=50-100 μg/kg) ，作为 RNA 聚合酶 II 的高选择性变构抑制剂。

生物活性	Fmoc-L-Asn(EDA-N3)-OH is aclick chemistryreagent containing an azide group. This building block is reported in literature for the modification of Amanitin viaClick Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal knownnatural products(LD50 = 50-100 μg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II^[1].
分子量	423.42
Formula	C₂₁H₂₁N₅O₅
CAS 号	2616562-74-2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.