16-Hydroxycleroda-3,13-dien-15,16-olide

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CAS NO:

141979-19-3

16ξ-Hydroxycleroda-3,13-dien-15,16-olide

16-Hydroxycleroda-3,13-dien-15,16-olide (16ξ-Hydroxycleroda-3,13-dien-15,16-olide; HCD) 是一种氯丹二萜，一种有效的丝氨酸蛋白酶二肽基肽酶 4 (DPP-4) 抑制剂。16-Hydroxycleroda-3,13-dien-15,16-olide 下调 LPS 诱导的肌细胞 ERK 磷酸化，阻断 GLP-1 诱导的 PKA 表达。16-Hydroxycleroda-3,13-dien-15,16-olide 具有降血脂、保肝、降血糖的功效。

生物活性	16-Hydroxycleroda-3,13-dien-15,16-olide (16ξ-Hydroxycleroda-3,13-dien-15,16-olide; HCD), a clerodane diterpene, is a potentserine proteasedipeptidyl peptidase4 (DPP-4)inhibitor. 16-Hydroxycleroda-3,13-dien-15,16-olide down-regulates LPS-inducedERKphosphorylation in myocyte but blocksGLP-1inducedPKAexpression. 16-Hydroxycleroda-3,13-dien-15,16-olide exhibits hypolipidemic, hepatoprotective, hypoglycemic efficacy^[1].
分子量	318.45
Formula	C₂₀H₃₀O₃
CAS 号	141979-19-3
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.