Etiprednol dicloacetate

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CAS NO:

199331-40-3

BNP 166
Etiprednol dichloroacetate

Etiprednol dicloacetate (BNP 166) 是一种抗炎剂。Etiprednol dicloacetate 抑制嗜酸性粒细胞的积累。Etiprednol dicloacetate 可用于哮喘等炎症性气管疾病的研究。

生物活性

Etiprednol dicloacetate (BNP 166) is an anti-inflammatory agent. Etiprednol dicloacetate inhibits eosinophil accumulation. Etiprednol dicloacetate can be used in the research of inflammatory airway diseases, such as asthma^[1]^[2].

体外研究
(In Vitro)

Etiprednol dicloacetate (1 nM-1 μM) inhibits LPS-induced TNF-α production by human blood^[1].

体内研究
(In Vivo)

Etiprednol dicloacetate (0-100 μg/kg, intranasal inhalation) attenuates peribronchial eosinophilia in the lung of the allergen sensitized and challenged rats^[1].
Etiprednol dicloacetate (0.1 μg/kg, intranasal inhalation) inhibits eosinophil accumulation in rats (antigen-induced airway eosinophil infiltration)^[3].
Etiprednol dicloacetate (0-20 mg/kg, p.o., 28 days) is well tolerated in rats and dogs^[2].

Animal Model:	Allergen sensitized and challenged Brown Norway rats^[1]
Dosage:	0.1, 1, 10, and 100 μg/kg
Administration:	Intranasal inhalation
Result:	Decreased the number of eosinophils at the perivascular area of the lung tissue. Decreased the number of mucus secreting cells and antigen-induced formation of perivascular edema.

Clinical Trial

分子量

485.40

Formula

C₂₄H₃₀Cl₂O₆

CAS 号

199331-40-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.