Nrf2/HO-1-IN-1

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Nrf2/HO-1-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

Nrf2/HO-1-IN-1 是一种有效的Nrf2/HO-1抑制剂，对NO的IC₅₀为 0.38 μM。Nrf2/HO-1-IN-1 可显著降低细胞中ROS水平。Nrf2/HO-1-IN-1 可用于抗炎研究。

生物活性

Nrf2/HO-1-IN-1 is a potentNrf2/HO-1pathway inhibitor, with anIC₅₀value of 0.38 μM forNO. Nrf2/HO-1-IN-1 can significantly reduce the level ofROSin cells. Nrf2/HO-1-IN-1 can be used for researching anti-inflammatory^[1].

IC₅₀& Target

IC₅₀: 0.38 μM (NO)^[1]

体外研究
(In Vitro)

Nrf2/HO-1-IN-1 (compound 23d) (0.25, 0.5, 1 and 2 μM; 3 hours) can reduce ROS production in RAW264.7 cells stimulated with LPS (0.5 μg/mL LPS stimulates for 12 hours)^[1].
Nrf2/HO-1-IN-1 (0.25, 0.5, 1 and 2 μM; 3 hours) significantly increases the expression of Nrf2 and HO-1 in LPS-stimulated RAW264.7 cells in a dose-dependent manner, and promoting LPS-induced Nrf2 nuclear translocation^[1]

Western Blot Analysis

Cell Line:	RAW264.7 (0.5 μg/mL LPS stimulates for 12 hours)^[1]
Concentration:	0.25, 0.5, 1 and 2 μM
Incubation Time:	3 hours
Result:	Significantly increased the expression of Nrf2 and HO-1 in a dose-dependent manner.

分子量

746.82

Formula

C₃₆H₄₆N₂O₁₃S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.