FPR2 agonist 2

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FPR2 agonist 2

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

FPR2 agonist 2 是一种有效的可透过血脑屏障的FPR2激动剂，h-FPR2的EC₅₀值为 0.13 μM。FPR2 agonist 2 抑制促炎细胞因子的产生，抵消线粒体功能的变化，并抑制 caspase-3 的活性。

生物活性

FPR2 agonist 2 is a potent and permeates the blood–brain barrierFPR2agonist with anEC₅₀of 0.13 μM, 1.1 μM for FPR2 and FPR1, respectively. FPR2 agonist 2 inhibits the production of pro-inflammatory cytokines, counterbalances the changes in mitochondrial function, and inhibits caspase-3 activity^[1].

IC₅₀& Target

EC₅₀: 0.13 μM (FPR2); 1.1 μM (FPR1)^[1]

体外研究
(In Vitro)

FPR2 agonist 2 (compound (S)-11l) (1-100 μM; 48 h) exhibits low cytotoxicity with an EC₅₀value of 20.8 μM in N9 cells^[1].
FPR2 agonist 2 (FPR1/FPR2 HL60 cells) shows agonist activity with EC₅₀s of 0.13 μM, 1.1 μM (IC₅₀s of 0.085 μM, Not determined) for FPR2 and FPR1, respectively^[1].
FPR2 agonist 2 (0.1 μM) effectively blocks LPS-induced cell death and NO production and effectively suppresses the effect of LPS stimulation^[1].
FPR2 agonist 2 (0.1 μM) counterbalances the changes in mitochondrial function, and inhibits caspase-3 activity^[1].

Cell Viability Assay^[1]

Cell Line:	N9 cells
Concentration:	1-100 μM
Incubation Time:	48 h
Result:	Exhibited low cytotoxicity with an EC₅₀value of 20.8 μM in N9 cells.

体内研究
(In Vivo)

FPR2 agonist 2 (1 mg/kg for i.v.; 10 mg/kg for i.p.) shows the ability to permeate the blood–brain barrier and to accumulate in the brain^[1].

Animal Model:	25-30 g, male CD-1 mice^[1]
Dosage:
Administration:	1 mg/kg for i.v.; 10 mg/kg for i.p. (dissolved in 5% DMSO, 10% solutol HS 15, and 85% sterile water)
Result:	Showed the ability to permeate the blood–brain barrier and to accumulate in the brain.

分子量

446.45

Formula

C₂₅H₂₀F₂N₄O₂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.