Oxacillin

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Oxacillin

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CAS NO:

66-79-5

苯唑西林

Oxacillin 是一种具有口服活性的合成青霉素，对葡萄球菌和其他革兰氏阳性病原体具有良好的杀菌 (bactericidal) 活性。

生物活性

Oxacillin is an orally active synthetic penicillin with goodbactericidalactivity against staphylococci and other gram-positive pathogens^[1].

体外研究
(In Vitro)

Oxacillin inhibits gram positive pathogens with MICs of 0.05, 0.09, 0.32 and 0.80 μg/mL against group A streptococci, Pneutnococci, susceptible staphylococci and penicillin-resistant staphylococci, respectively^[1].
The Oxacillin-resistant strains are highly resistant to other penicillins^[1].

体内研究
(In Vivo)

Oxacillin (50-800 mg/kg; s.c.; once) shows curative dose (CD₅₀) of 253.3 mg/kg in mice infected withStaphylococcus aureusEvans. The oral CD₅₀of Oxacillin is 187.2 mg/kg^[2].

Animal Model:	CD-1 strain male albino mice infected withS. aureusEvans^[2]
Dosage:	50, 100, 200, 400 and 800 mg/kg
Administration:	Subcutaneous injection, once
Result:	Showed therapeutic activity with CD₅₀of 253.3 mg/kg.

Clinical Trial

分子量

401.44

Formula

C₁₉H₁₉N₃O₅S

CAS 号

66-79-5

中文名称

苯唑西林

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.