Amphomycin

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Amphomycin

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CAS NO:

1402-82-0

Amphomycin 是一种脂肽抗生素，能抑制肽聚糖合成并阻断细胞壁发育。Amphomycin 对耐甲氧西林金黄色葡萄球菌 (MRSA)、耐万古霉素肠球菌 (VRE)、耐青霉素-庆大霉素-红霉素肺炎链球菌和耐利奈唑胺-奎奴普汀-达福普汀肠球菌表现出有效的抗菌活性。

生物活性

Amphomycin is alipopeptideantibiotic that inhibits peptidoglycan synthesis and blocks cell wall development. Amphomycin exhibits potent antibacterial activities against methicillin-resistantS. aureus(MRSA), vancomycin-resistant enterococci (VRE), penicillin-gentamicin-erythromycin-resistantS. pneumonia, and linezolid-quinupristin-dalfopristin-resistant enterococci^[1]^[2]^[3].

体外研究
(In Vitro)

Amphomycin (40 μ g/mL; 60 min) leadsS. aureusto exhibit cell wall thinning and Park’s nucleotide accumulation^[1].

Cell Viability Assay^[1]

Cell Line:	S. aureuswhole cells
Concentration:	40 μ g/mL
Incubation Time:	60 min
Result:	Resulted in the thinning of cell wall and the accumulation of Park’s nucleotide.

体内研究
(In Vivo)

Amphomycin (50 mg/kg; p.o.; single) shows low oral availability and (5-10mg/kg; i.v.; single) exhibits a long half-life (5.2-8.0 h in mice and 4.6-7.1 h in rats)^[2].

CAS 号

1402-82-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.