Fobrepodacin

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Fobrepodacin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1384984-31-9

SPR720
pVXc-486

Fobrepodacin (SPR720) 是一种具有口服活性的，有效的 SPR719 (VXc-486; HY-12930) 磷酸盐前药。Fobrepodacin 在体内具有很好的杀菌 (bactericidal) 活性。

生物活性

Fobrepodacin (SPR720) is an orally active and potent phosphate prodrug of SPR719 (VXc-486; HY-12930). Fobrepodacin has potentbactericidalactivities in vivo^[1].

体内研究
(In Vivo)

Fobrepodacin (oral gavage; 10, 30, 100 mg/kg; once per day; 5 times per week for 4 weeks) reduces the mycobacterial burden in a model of chronic tuberculosis infection in mice^[1].
Fobrepodacin (oral; 100 mg/kg; once per day; 5 days per week, for 8 weeks) improves the bactericidal activities of antimycobacterial drugs^[1].

Animal Model:	Six-week old female BALB/c and C57BL/6 mice uninfected or M. tuberculosis-infected (Erdman)^[1]
Dosage:	10, 30, 100 mg/kg
Administration:	Oral gavage; once per day; 5 times per week for 4 weeks
Result:	Reduced the mycobacterial burden in a model of chronic tuberculosis infection in mice.

Clinical Trial

分子量

508.44

Formula

C₂₁H₂₆FN₆O₆P

CAS 号

1384984-31-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.