TCS 2510

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TCS 2510

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	346673-06-1
包装:	500μg(13.04 mM * 100 μL in ethanol)
市场价:	5500元

CAY10598

TCS 2510 是一种选择性EP4激动剂。TCS 2510 可用于代谢疾病的研究。

生物活性

TCS 2510 is a selectiveEP4agonist. TCS 2510 can be used for the research of metabolic diseases^[1].

IC₅₀& Target

EP4^[1]

体外研究
(In Vitro)

TCS 2510 (0.001~100 μM; GLUTag cells) stimulates glucagon like peptide 1 secretion. TCS2510 activates the Gas signaling pathway. TCS 2510 (10 μM; 2~24 h; GLUTag cells) increases the Gcg mRNA expression levels. TCS 2510 produces a concentration dependent increase in cAMP levels in GLUTag cells with EC₅₀of 20 nM and the maximal stimulation of 60 % over the basal cAMP levels. The decrease in cell impedance in GLUTag cells observed with TCS 2510 is concentration dependent with IC₅₀of 15 nM. TCS 2510 produces a concentration-dependent increase in glucagon like peptide 2 secretion in GLUTag cells^[1].

体内研究
(In Vivo)

TCS 2510 (0.1~10 mg/kg; p.o.) produces a dose-dependent elevation in plasma glucagon like peptide 1 levels in fasted mice measured 15 min after compound administration^[1].
TCS 2510 (10 mg/kg; p.o.) increases plasma glucagon like peptide 1 levels up to 8-fold over the basal hormone levels^[1].
TCS 2510 (1~10 mg/kg; p.o) affords a significant elevation in plasma glucagon like peptide 2 levels^[1]

Animal Model:	Mice^[1]
Dosage:	0.1~10 mg/kg
Administration:	P.o.
Result:	Produced a dose-dependent elevation in plasma glucagon like peptide 1 levels in fasted mice measured 15 min after compound administration.

Animal Model:	Mice^[1]
Dosage:	10 mg/kg
Administration:	P.o.
Result:	Increased plasma glucagon like peptide 1 levels up to 8-fold over the basal hormone levels.

Animal Model:	Mice^[1]
Dosage:	1~10 mg/kg
Administration:	P.o.
Result:	Afforded a significant elevation in plasma glucagon like peptide 2 levels.

分子量

383.49

性状

Liquid

Formula

C₂₁H₂₉N₅O₂

CAS 号

346673-06-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Solution, -20°C, 2 years