NaV1.2/1.6 channel blocker-1 是一种有效的NaV1.2/1.6 channel阻滞剂，抑制rNaV1.6和hNaV1.2的IC50值分别为 9.8 和 24.4 μM。NaV1.2/1.6 channel blocker-1 可用于全身性癫痫的研究。
| 生物活性 | NaV1.2/1.6 channel blocker-1 is a potentNaV1.2/1.6 channelblocker, withIC50s of 9.8 and 24.4 μM forrNaV1.6andhNaV1.2, respectively. NaV1.2/1.6 channel blocker-1 can be used for the research of generalized epilepsy[1]. |
| IC50& Target[1] | rNaV1.6 9.8 μM (IC50) | hNaV1.2 24.4 μM (IC50) |
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体外研究
(In Vitro) | NaV1.2/1.6 channel blocker-1 (compound 13) (1-100 μM) 在稳定表达大鼠 NaV1.6 和人 NaV1.2 同种型的 HEK 293 细胞中分别阻断 48.5% 和 34.0% 的 NaV1.6 和 NaV1.2 钠电流[1]。
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
