Alexidine

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Alexidine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

22573-93-9

Alexidine 是一种双双胍，对多种真菌病原体具有抗真菌 (antifungal) 和抗生物膜活性。Alexidine 还具有一种抗肿瘤活性，靶向哺乳动物细胞中的线粒体酪氨酸磷酸酶PTPMT1，并导致线粒体凋亡 (apoptosis)。

生物活性

Alexidine, a bis-biguanide, exhibitsantifungaland antibiofilm activity against a diverse range offungalpathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosinephosphatase,PTPMT1, in mammalian cells and causes mitochondrialapoptosis^[1].

体外研究
(In Vitro)

Alexidine (10 μM, 24 hours) treatment can decimate the biofilm community^[1].
Alexidine (0-60 μg/ml, 24 hours) treatment can kill HUVECs and lung A549 cells^[1].

Cell Viability Assay^[1]

Cell Line:	C. albicans,C. auris,A. fumigatus
Concentration:	10 μM
Incubation Time:	24 hours
Result:	Could significantly kill 80% of mature biofilm community.

Cell Viability Assay^[1]

Cell Line:	HUVECs, lung A549 cells
Concentration:	0-60 μg/ml
Incubation Time:	24 hours
Result:	resulted in 50% killing of HUVECs and lung A549 cells ( CC₅₀>7.37 μg/ml ).

体内研究
(In Vivo)

Alexidine (Jugular vein-catheterized; 48 hours; 3 μg/ml; once) can decimate preformed biofilms growing in the jugular vein catheters of mice^[1].

Animal Model:	8-week-old C57BL/6 male mice
Dosage:	3 μg/ml
Administration:	Jugular vein-catheterized, 48 hours, 3 μg/ml, once
Result:	Inhibited 67% of fungal biofilm growth and viability, compared to the control untreated biofilms.

分子量

508.79

Formula

C₂₆H₅₆N₁₀

CAS 号

22573-93-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.