Darinaparsin (ZIO-101), an organic arsenical, is a mitochondrial-targeted agent. Darinaparsin inducesapoptosisin ancer cells, and has anticancer effects^[1].

Darinaparsin is cytotoxic to prostate cancer cell lines as well as fresh prostate cancer cells at low micromolar concentrations, and importantly inhibits the termed tumor-initiating cells (TIC) subpopulations^[1].

Darinaparsin inhibits growth of the castrate-resistant Du145 prostate tumor propagated as xenograft in mice and inhibits the tumor-initiating potential of prostate cancer cells^[1].

411.31

C₁₂H₂₂AsN₃O₆S

69819-86-9

Room temperature in continental US; may vary elsewhere.

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