Dihydroeponemycin

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Dihydroeponemycin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

126463-64-7

Dihydroeponemycin, 是抗肿瘤和抗血管生成天然产物埃普霉素的类似物，选择性靶向 20S 蛋白酶体 (20S proteasome)。Dihydroeponemycin 共价修饰催化蛋白酶体亚单位的子集，优先与IFN-γ 诱导亚单位 LMP2 和 LMP7 结合Dihydroeponemycin 介导的蛋白酶体抑制诱导纺锤样细胞形态变化和细胞凋亡 (apoptosis)。

生物活性	Dihydroeponemycin, an analogue of the antitumor and antiangiogenic natural product eponemycin, selectively targets the20Sproteasome. Dihydroeponemycin covalently modifies a subset of catalytic proteasomal subunits, binding preferentially to the IFN-gamma-inducible subunits LMP2 and LMP7. Dihydroeponemycin-mediatedproteasomeinhibition induces a spindle-like cellular morphological change andapoptosis^[1].
分子量	400.51
Formula	C₂₀H₃₆N₂O₆
CAS 号	126463-64-7
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.