Difopein (TFA), a specific and competitive inhibitor of14-3-3 protein(a highly conserved eukaryotic regulatory molecule), blocking the ability of 14-3-3 to bind to target proteins and inhibits 14-3-3/Ligand interactions. Difopein (TFA) leads to induction ofapoptosisand enhances the ability of cisplatin to kill cells^[1].

14-3-3 protein^[1]

6501.19

Solid

C₂₇₅H₄₂₅N₇₆F₃O₉₁S₆

SADGAPHCVPRDLSWLDLEANMCLPGAAGLDSADGAPHCVPRDLSWLDLEANMCLPGAAGLE

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)