Dimethindene maleate

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CAS NO:

3614-69-5

Dimethindene maleate 是一种选择性的histamine H1拮抗剂，具有抗组胺效应。Dimethindene maleate 可用于过敏性反应的研究。

生物活性

Dimethindene maleate is a selectivehistamine H1antagonist with antihistamine effects. Dimethindene maleate can be used for the research of hypersensitivity reactions^[1]^[2]^[3].

IC₅₀& Target

Human Endogenous Metabolite

体外研究
(In Vitro)

Dimethindene maleate (1-1000 μM) suppresses the cromakalim-induced/glibenclamide-sensitive K^＋currents in a concentration-dependent and reversible manner with an IC₅₀value of 29.5 μM^[2].
Dimethindene maleate (1-1000 μM) inhibits Y-26763-induced glibenclamide-sensitive K^＋currents with an IC₅₀value of 49 μM^[2].

体内研究
(In Vivo)

Dimethindene maleate (0.25 mg; i.p. once) affects wound healing in mice^[1].

Animal Model:	C57BL/6 mice with wound healing^[1]
Dosage:	0.25 mg
Administration:	Intraperitoneal injection; 0.25 mg once
Result:	Significantly delayed skin wound and only showed wound closure impairment in the initial phase wound healing.

分子量

408.49

性状

Solid

Formula

C₂₄H₂₈N₂O₄

CAS 号

3614-69-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)