NGB 2904 是一种具有口服活性和选择性的多巴胺(DA) D3受体拮抗剂。NGB 2904 可用于可卡因成瘾的研究。
| 生物活性 | NGB 2904 is an orally active and selectivedopamine (DA)D3receptorantagonist. NGB 2904 can be used for the research of cocaine addiction[1]. |
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体内研究
(In Vivo) | NGB 2904 (0.1~5 mg/kg; i.p.) significantly loweres the break-point for cocaine self-administration behavior reinforced under progressive-ratio conditions and significantly inhibits cocaine-triggered reinstatement of drug-seeking behavior in rats extinguished from daily cocaine self-administration[1].
NGB 2904 (0~10 mg/kg; i.p.) administered 30 min prior to the beginning of daily cocaine self-administration sessions has no significant effect on cocaine self-administration behavior at a unit cocaine reinforcement dose of 0.5 mg/kg/infusion compared to vehicle-treated animals. NGB 2904 (0.1 and 1 mg/kg) pretreatment significantly inhibits the enhanced brain stimulation reward produced by 2 mg/kg, but not by 10 mg/kg, of cocaine. NGB 2904 pretreatment produces a significant attenuation of this cocaine-triggered reinstatement of drug-seeking[1].
| Animal Model: | Male Long–Evans rats (250–300 g)[1] | | Dosage: | 0.1~5 mg/kg | | Administration: | I.p.; | | Result: | Significantly lowered the break-point for cocaine self-administration behavior reinforced under progressive-ratio conditions and significantly inhibited cocaine-triggered reinstatement of drug-seeking behavior in rats extinguished from daily cocaine self-administration. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| 溶解性数据 | In Vitro: Ethanol : 4.55 mg/mL(9.20 mM;ultrasonic and warming and heat to 60℃) 配制储备液 | 1 mM | 2.0224 mL | 10.1120 mL | 20.2241 mL | | 5 mM | 0.4045 mL | 2.0224 mL | 4.0448 mL | | 10 mM | --- | --- | --- |
*请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。 |
