MtMetAP1-IN-1 is an inhibitor ofMycobacterium tuberculosis(Mtb), targetingmethionineaminopeptidase1(MetAP1). MtMetAP1-IN-1 exerts antimycobacterial activity^[1].

methionine aminopeptidase 1 (MetAP1)^[1]

MetAP1 is known to work in the presence of various divalent cations, is considered to acts function with a most probable cofactor, iron (Fe²⁺)^[1].
MtMetAP1-IN-1 (compound 12) (12.5 μM) inhibits MtMetAP1 under different metals catalytic effect with residual activity RA (%) of 51% (Co²⁺), 21% (Ni²⁺), 33% (Fe²⁺)^[1].
MtMetAP1-IN-1 has a preference towards Ni²⁺, inhibits MtMetAP1 with an IC₅₀value of with 0.7 μM^[1].

404.24

C₁₅H₁₀BrN₅O₂S

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