A68930

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A68930

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

130465-45-1

A68930 作为dopamine D1 receptor激动剂，可用于支气管扩张的研究。

生物活性

A68930, as adopamine D1 receptoragonist, can be used for the research of bronchiectasis^[1].

IC₅₀& Target

D₁Receptor

体外研究
(In Vitro)

A68930 (1 μM; 5-60 minutes; 16HBE14o- or NCI-H292 cells) significantly increases phosphorylation of cAMP response element binding (CREB) protein^[1].
A68930 (1 μM; 48 hours; NCI-H292 cells) induces MUC5AC mRNA expression and increases the mRNA data of MUC5AC and MUC5AC protein expression^[1].
A68930 (1 μM; 20 minutes; NCI-H292 cells) significantly increases intracellular cAMP levels^[1].

Western Blot Analysis^[1]

Cell Line:	16HBE14o- or NCI-H292 cells
Concentration:	1 μM
Incubation Time:	5~60 minutes
Result:	Significantly increased phosphorylation of CREB.

RT-PCR^[1]

Cell Line:	NCI-H292 cells
Concentration:	1 μM
Incubation Time:	48 hours
Result:	Induced MUC5AC mRNA expression.

Immunofluorescence^[1]

Cell Line:	NCI-H292 cells
Concentration:	1 μM
Incubation Time:	48 hours
Result:	The mRNA data of MUC5AC, MUC5AC protein expression were increased.

分子量

271.31

Formula

C₁₆H₁₇NO₃

CAS 号

130465-45-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.